Interleukin 21 Receptor (IL21R) (Middle Region) Peptide
IL21R
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5511292
Quick Overview for Interleukin 21 Receptor (IL21R) (Middle Region) Peptide (ABIN5511292)
Target
IL21 Receptor (IL21R)
(Interleukin 21 Receptor (IL21R))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- SDGVPKPSFW PTAQNSGGSA YSEERDRPYG LVSIDTVTVL DAEGPCTWPC
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- IL21R Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))
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Background
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The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.
Alias Symbols: NILR, CD360
Protein Size: 538 -
Gene ID
- 50615
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NCBI Accession
- NM_021798, NP_068570
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UniProt
- Q9HBE5
Target
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